Rational design of aptamer switches with programmable pH response

Aptamer switches that respond sensitively to pH could enhance control over molecular devices, improving their diagnostic and therapeutic efficacy. Previous designs have inserted pH-sensitive DNA motifs into aptamer sequences. Unfortunately, their performance was limited by the motifs’ intrinsic pH-r...

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Detalles Bibliográficos
Autores principales: Thompson, Ian A. P., Zheng, Liwei, Eisenstein, Michael, Soh, H. Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286914/
https://www.ncbi.nlm.nih.gov/pubmed/32522989
http://dx.doi.org/10.1038/s41467-020-16808-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286914/
https://www.ncbi.nlm.nih.gov/pubmed/32522989
http://dx.doi.org/10.1038/s41467-020-16808-2

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