Selective stimulation of colonic L cells improves metabolic outcomes in mice

AIMS/HYPOTHESIS: Insulin-like peptide-5 (INSL5) is found only in distal colonic L cells, which co-express glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). GLP-1 is a well-known insulin secretagogue, and GLP-1 and PYY are anorexigenic, whereas INSL5 is considered orexigenic. We aimed to clarify...

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Detalles Bibliográficos
Autores principales: Lewis, Jo E., Miedzybrodzka, Emily L., Foreman, Rachel E., Woodward, Orla R. M., Kay, Richard G., Goldspink, Deborah A., Gribble, Fiona M., Reimann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286941/
https://www.ncbi.nlm.nih.gov/pubmed/32342115
http://dx.doi.org/10.1007/s00125-020-05149-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286941/
https://www.ncbi.nlm.nih.gov/pubmed/32342115
http://dx.doi.org/10.1007/s00125-020-05149-w

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