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In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation
The tumor immune microenvironment (TIME) of head and neck squamous cell carcinomas (HNSCC) and other solid malignancies is a key determinant of therapy response and prognosis. Among other factors, it is shaped by the tumor mutational burden and defects in DNA repair enzymes. Based on the TCGA databa...
Autores principales: | Krupar, Rosemarie, Watermann, Christian, Idel, Christian, Ribbat-Idel, Julika, Offermann, Anne, Pasternack, Helen, Kirfel, Jutta, Sikora, Andrew G., Perner, Sven |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287052/ https://www.ncbi.nlm.nih.gov/pubmed/32523042 http://dx.doi.org/10.1038/s41598-020-66329-7 |
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