Cargando…
Comparison of AAV-Mediated Optogenetic Vision Restoration between Retinal Ganglion Cell Expression and ON Bipolar Cell Targeting
The loss of photoreceptors in individuals with retinal degenerative diseases leads to partial or complete blindness. Optogenetic therapy is a promising approach for restoring vision to the blind. Multiple strategies have been employed by targeting genetically encoded light sensors, particularly chan...
Autores principales: | Lu, Qi, Ganjawala, Tushar H., Krstevski, Andrea, Abrams, Gary W., Pan, Zhuo-Hua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287188/ https://www.ncbi.nlm.nih.gov/pubmed/32548211 http://dx.doi.org/10.1016/j.omtm.2020.05.009 |
Ejemplares similares
-
A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration
por: Lu, Qi, et al.
Publicado: (2018) -
rAAV-Mediated Subcellular Targeting of Optogenetic Tools in Retinal Ganglion Cells In Vivo
por: Wu, Chaowen, et al.
Publicado: (2013) -
Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing Cre transgenic mouse lines
por: Lu, Qi, et al.
Publicado: (2013) -
ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration
por: Pan, Zhuo-Hua, et al.
Publicado: (2014) -
Optogenetic restoration of retinal ganglion cell activity in the living primate
por: McGregor, Juliette E., et al.
Publicado: (2020)