Retinal Degeneration Caused by Rod-Specific Dhdds Ablation Occurs without Concomitant Inhibition of Protein N-Glycosylation

Dehydrodolichyl diphosphate synthase (DHDDS) catalyzes the committed step in dolichol synthesis. Recessive mutations in DHDDS cause retinitis pigmentosa (RP59), resulting in blindness. We hypothesized that rod photoreceptor-specific ablation of Dhdds would cause retinal degeneration due to diminishe...

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Detalles Bibliográficos
Autores principales: Ramachandra Rao, Sriganesh, Skelton, Lara A., Wu, Fuguo, Onysk, Agnieszka, Spolnik, Grzegorz, Danikiewicz, Witold, Butler, Mark C., Stacks, Delores A., Surmacz, Liliana, Mu, Xiuqian, Swiezewska, Ewa, Pittler, Steven J., Fliesler, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287266/
https://www.ncbi.nlm.nih.gov/pubmed/32526701
http://dx.doi.org/10.1016/j.isci.2020.101198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287266/
https://www.ncbi.nlm.nih.gov/pubmed/32526701
http://dx.doi.org/10.1016/j.isci.2020.101198

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