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β(2)-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP
TAPP (H-Tyr-d-Ala-Phe-Phe-NH(2)) is a potent, µ-selective opioid ligand. In order to gain further insights into pharmacophoric features of this tetrapeptide, we have performed a β(2)-Homo-amino acid (β(2)hAA) scan of the TAPP sequence. To this aim, 10 novel analogues have been synthesized and evalua...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288052/ https://www.ncbi.nlm.nih.gov/pubmed/32466333 http://dx.doi.org/10.3390/molecules25102461 |