Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on t...

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Autores principales: Milazzo, Giorgio, Mercatelli, Daniele, Di Muzio, Giulia, Triboli, Luca, De Rosa, Piergiuseppe, Perini, Giovanni, Giorgi, Federico M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288346/
https://www.ncbi.nlm.nih.gov/pubmed/32429325
http://dx.doi.org/10.3390/genes11050556
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author Milazzo, Giorgio
Mercatelli, Daniele
Di Muzio, Giulia
Triboli, Luca
De Rosa, Piergiuseppe
Perini, Giovanni
Giorgi, Federico M.
author_facet Milazzo, Giorgio
Mercatelli, Daniele
Di Muzio, Giulia
Triboli, Luca
De Rosa, Piergiuseppe
Perini, Giovanni
Giorgi, Federico M.
author_sort Milazzo, Giorgio
collection PubMed
description Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes.
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spelling pubmed-72883462020-06-17 Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability Milazzo, Giorgio Mercatelli, Daniele Di Muzio, Giulia Triboli, Luca De Rosa, Piergiuseppe Perini, Giovanni Giorgi, Federico M. Genes (Basel) Review Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes. MDPI 2020-05-15 /pmc/articles/PMC7288346/ /pubmed/32429325 http://dx.doi.org/10.3390/genes11050556 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Milazzo, Giorgio
Mercatelli, Daniele
Di Muzio, Giulia
Triboli, Luca
De Rosa, Piergiuseppe
Perini, Giovanni
Giorgi, Federico M.
Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
title Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
title_full Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
title_fullStr Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
title_full_unstemmed Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
title_short Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
title_sort histone deacetylases (hdacs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288346/
https://www.ncbi.nlm.nih.gov/pubmed/32429325
http://dx.doi.org/10.3390/genes11050556
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