Transcriptomic and Proteostasis Networks of CFTR and the Development of Small Molecule Modulators for the Treatment of Cystic Fibrosis Lung Disease

Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The diversity of mutations and the multiple ways by which the protein is affected present challenges for therapeutic development. The observation that the Phe50...

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Detalles Bibliográficos
Autores principales: Strub, Matthew D., McCray, Jr., Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288469/
https://www.ncbi.nlm.nih.gov/pubmed/32414011
http://dx.doi.org/10.3390/genes11050546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288469/
https://www.ncbi.nlm.nih.gov/pubmed/32414011
http://dx.doi.org/10.3390/genes11050546

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