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Development of human prostate cancer stem cells involves epigenomic alteration and PI3K/AKT pathway activation

BACKGROUND: Human prostate cancer spheres endowed with stem cell properties have been obtained from androgen-dependent cell line LNCaP after exposure to an epigenomic modulator phenethyl isothiocynate (PEITC). Sphere cells can self-renew and grow with androgen, and also without androgen. Little is k...

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Detalles Bibliográficos
Autores principales:	Wu, Jingjing, Cang, Shundong, Liu, Christina, Ochiai, Whitman, Chiao, Jen Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288500/ https://www.ncbi.nlm.nih.gov/pubmed/32537260 http://dx.doi.org/10.1186/s40164-020-00168-0

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