A mutation that blocks integrin α(4)β(7) activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis

BACKGROUND: β(7) integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin α(4)β(7) binds MAdCAM-1, mediating rolling adhesion of lymphocytes on blood vessel walls when inactive and firm adhesion when activa...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hailong, Zheng, Yajuan, Pan, Youdong, Lin, Changdong, Wang, Shihui, Yan, Zhanjun, Lu, Ling, Ge, Gaoxiang, Li, Jinsong, Zeng, Yi Arial, Chen, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288534/
https://www.ncbi.nlm.nih.gov/pubmed/32522281
http://dx.doi.org/10.1186/s12915-020-00784-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288534/
https://www.ncbi.nlm.nih.gov/pubmed/32522281
http://dx.doi.org/10.1186/s12915-020-00784-6

Ejemplares similares