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A mutation that blocks integrin α(4)β(7) activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis

BACKGROUND: β(7) integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin α(4)β(7) binds MAdCAM-1, mediating rolling adhesion of lymphocytes on blood vessel walls when inactive and firm adhesion when activa...

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Detalles Bibliográficos
Autores principales:	Zhang, Hailong, Zheng, Yajuan, Pan, Youdong, Lin, Changdong, Wang, Shihui, Yan, Zhanjun, Lu, Ling, Ge, Gaoxiang, Li, Jinsong, Zeng, Yi Arial, Chen, Jianfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288534/ https://www.ncbi.nlm.nih.gov/pubmed/32522281 http://dx.doi.org/10.1186/s12915-020-00784-6

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