Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A

[Image: see text] Lactate dehydrogenase A (LDHA) is frequently overexpressed in tumors, thereby sustaining high glycolysis rates, tumor growth, and chemoresistance. High-throughput screening resulted in the identification of phthalimide and dibenzofuran derivatives as novel lactate dehydrogenase inh...

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Detalles Bibliográficos
Autores principales: Friberg, Anders, Rehwinkel, Hartmut, Nguyen, Duy, Pütter, Vera, Quanz, Maria, Weiske, Jörg, Eberspächer, Uwe, Heisler, Iring, Langer, Gernot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288559/
https://www.ncbi.nlm.nih.gov/pubmed/32548488
http://dx.doi.org/10.1021/acsomega.0c00715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288559/
https://www.ncbi.nlm.nih.gov/pubmed/32548488
http://dx.doi.org/10.1021/acsomega.0c00715

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