Derivatives of a PARP Inhibitor TIQ-A through the Synthesis of 8-Alkoxythieno[2,3-c]isoquinolin-5(4H)-ones

[Image: see text] Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through the inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family, potentially limiting its usability. The broad inhibiti...

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Detalles Bibliográficos
Autores principales: Maksimainen, Mirko M., Nurmesjärvi, Antti, Terho, Reima A., Threadgill, Michael D., Lehtiö, Lari, Heiskanen, Juha P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288715/
https://www.ncbi.nlm.nih.gov/pubmed/32548533
http://dx.doi.org/10.1021/acsomega.0c01879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288715/
https://www.ncbi.nlm.nih.gov/pubmed/32548533
http://dx.doi.org/10.1021/acsomega.0c01879

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