NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain

The release and nuclear translocation of the intracellular domain of Notch receptor (NICD) is the prerequisite for Notch signaling-mediated transcriptional activation. NICD is subjected to various posttranslational modifications including ubiquitination. Here, we surprisingly found that NUMB protein...

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Detalles Bibliográficos
Autores principales: Luo, Zhiyuan, Mu, Lili, Zheng, Yue, Shen, Wenchen, Li, Jiali, Xu, Lichao, Zhong, Bo, Liu, Ying, Zhou, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288735/
https://www.ncbi.nlm.nih.gov/pubmed/31504682
http://dx.doi.org/10.1093/jmcb/mjz088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288735/
https://www.ncbi.nlm.nih.gov/pubmed/31504682
http://dx.doi.org/10.1093/jmcb/mjz088

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