Cargando…

NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain

The release and nuclear translocation of the intracellular domain of Notch receptor (NICD) is the prerequisite for Notch signaling-mediated transcriptional activation. NICD is subjected to various posttranslational modifications including ubiquitination. Here, we surprisingly found that NUMB protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Zhiyuan, Mu, Lili, Zheng, Yue, Shen, Wenchen, Li, Jiali, Xu, Lichao, Zhong, Bo, Liu, Ying, Zhou, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288735/ https://www.ncbi.nlm.nih.gov/pubmed/31504682 http://dx.doi.org/10.1093/jmcb/mjz088

Ejemplares similares

Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics
por: Ferrante, Francesca, et al.
Publicado: (2022)

High levels of Notch signaling down-regulate Numb and Numblike
por: Chapman, Gavin, et al.
Publicado: (2006)

Rewired Notch/p53 by Numb’ing Mdm2
por: Kim, Hyungsoo, et al.
Publicado: (2018)

Expression of Notch1 and Numb in small cell lung cancer
por: Kikuchi, Hajime, et al.
Publicado: (2017)

Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling
por: Shu, Yuke, et al.
Publicado: (2021)

Notch intracellular domain regulates glioblastoma proliferation through the Notch1 signaling pathway
por: Wang, Yixuan, et al.
Publicado: (2021)

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
por: Pece, Salvatore, et al.
Publicado: (2004)

Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling
por: Bocci, Federico, et al.
Publicado: (2017)

The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis
por: Miao, Lianjie, et al.
Publicado: (2021)

Ubiquitinations in the Notch Signaling Pathway
por: Moretti, Julien, et al.
Publicado: (2013)

Notch Intracellular Domain Expression in Various Skin Fibroproliferative Diseases
por: Kim, Jung-Eun, et al.
Publicado: (2014)

Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice
por: Chartoumpekis, Dionysios V., et al.
Publicado: (2015)

The function of Notch1 intracellular domain in the differentiation of gastric cancer
por: Hu, Sunkuan, et al.
Publicado: (2018)

The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation
por: Hounjet, Judith, et al.
Publicado: (2021)

Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
por: Blokzijl, Andries, et al.
Publicado: (2003)

Loss of nuclear NOTCH1, but not its negative regulator NUMB, is an independent predictor of cervical malignancy
por: Vázquez-Ulloa, Elenaé, et al.
Publicado: (2018)

NOTCH1 Intracellular Domain and the Tumor Microenvironment as Prognostic Markers in HNSCC
por: Schmidl, Benedikt, et al.
Publicado: (2022)

Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
por: Wang, Miaoxing, et al.
Publicado: (2021)

Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules
por: Messerschmidt, Victoria L., et al.
Publicado: (2021)

RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain
por: Bridges, Esther, et al.
Publicado: (2020)

Numb Independently Antagonizes Sanpodo Membrane Targeting and Notch Signaling in Drosophila Sensory Organ Precursor Cells
por: Tong, Xin, et al.
Publicado: (2010)

Aberrant expression of Notch1/numb/snail signaling, an epithelial mesenchymal transition related pathway, in adenomyosis
por: Qi, Shasha, et al.
Publicado: (2015)

Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear
por: Eddison, Mark, et al.
Publicado: (2015)

Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells
por: Johnson, Seth A., et al.
Publicado: (2016)

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
por: Zhang, Jianchao, et al.
Publicado: (2016)

Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study
por: Gonulcu, Sinem Cil, et al.
Publicado: (2020)

SAT-348 Overexpression of the Notch Intracellular Domain Results in Abnormal Adrenal Development.
por: Reid, Olivia, et al.
Publicado: (2019)

Enhanced Delta-Notch Lateral Inhibition Model Incorporating Intracellular Notch Heterogeneity and Tension-Dependent Rate of Delta-Notch Binding that Reproduces Sprouting Angiogenesis Patterns
por: Koon, Yen Ling, et al.
Publicado: (2018)

Corrigendum: Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules
por: Messerschmidt, Victoria L., et al.
Publicado: (2021)

Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation
por: Pan, Leiling, et al.
Publicado: (2021)

Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis
por: Liu, Tingyan, et al.
Publicado: (2023)

Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites
por: Gazdik, Tana R., et al.
Publicado: (2023)

Differential expression of Notch1 intracellular domain and p21 proteins, and their clinical significance in gastric cancer
por: LUO, DING-HAI, et al.
Publicado: (2014)

Exclusion of NUMB Exon12 Controls Cancer Cell Migration through Regulation of Notch1-SMAD3 Crosstalk
por: Zhan, Zheng, et al.
Publicado: (2022)

MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy
por: Li, Meng-Ran, et al.
Publicado: (2022)

Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking
por: Urata, Yusuke, et al.
Publicado: (2020)

Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis
por: Roy, A, et al.
Publicado: (2012)

Notch family members follow stringent requirements for intracellular domain dimerization at sequence-paired sites
por: Crow, Jacob J., et al.
Publicado: (2020)

ADAM10-Initiated Release of Notch Intracellular Domain Regulates Microtubule Stability and Radial Migration of Cortical Neurons
por: Yang, Zhi, et al.
Publicado: (2017)

Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling
por: Farshbaf, Mozhgan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9d5rlk8g6ugdjiao1cb43dbm4j