PI3K-Akt-mTOR inhibition by GNE-477 inhibits renal cell carcinoma cell growth in vitro and in vivo

Sustained activation of PI3K-Akt-mTOR cascade is important for renal cell carcinoma (RCC) cell progression. GNE-477 is a novel and efficacious PI3K-mTOR dual inhibitor. The current study tested its anti-RCC cell activity. In the primary cultured human RCC cells, GNE-477 potently inhibited cell growt...

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Detalles Bibliográficos
Autores principales: Ye, Xueting, Ruan, Jian-Wei, Huang, Hang, Huang, Wei-Ping, Zhang, Yan, Zhang, Fangyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288912/
https://www.ncbi.nlm.nih.gov/pubmed/32421688
http://dx.doi.org/10.18632/aging.103221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288912/
https://www.ncbi.nlm.nih.gov/pubmed/32421688
http://dx.doi.org/10.18632/aging.103221

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