Structural analysis of the putative SARS-CoV-2 primase complex

We report the crystal structure of the SARS-CoV-2 putative primase composed of the nsp7 and nsp8 proteins. We observed a dimer of dimers (2:2 nsp7-nsp8) in the crystallographic asymmetric unit. The structure revealed a fold with a helical core of the heterotetramer formed by both nsp7 and nsp8 that...

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Detalles Bibliográficos
Autores principales: Konkolova, Eva, Klima, Martin, Nencka, Radim, Boura, Evzen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289108/
https://www.ncbi.nlm.nih.gov/pubmed/32535228
http://dx.doi.org/10.1016/j.jsb.2020.107548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289108/
https://www.ncbi.nlm.nih.gov/pubmed/32535228
http://dx.doi.org/10.1016/j.jsb.2020.107548

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