Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase

• There is amino acid sequence homology between the ADP-ribose binding sites of human PARP14 and SARS-CoV-2 ADRP. • This homology is even more pronounced in bat species. • The model proposed highlights the potential of the PARP axis to yield druggable targets for the treatment of COVID-19.

Detalles Bibliográficos
Autores principales: Webb, Thomas E., Saad, Ramy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Federation of Immunological Societies. Published by Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289111/
https://www.ncbi.nlm.nih.gov/pubmed/32534867
http://dx.doi.org/10.1016/j.imlet.2020.05.008
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author Webb, Thomas E.
Saad, Ramy
author_facet Webb, Thomas E.
Saad, Ramy
author_sort Webb, Thomas E.
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description • There is amino acid sequence homology between the ADP-ribose binding sites of human PARP14 and SARS-CoV-2 ADRP. • This homology is even more pronounced in bat species. • The model proposed highlights the potential of the PARP axis to yield druggable targets for the treatment of COVID-19.
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spelling pubmed-72891112020-06-12 Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase Webb, Thomas E. Saad, Ramy Immunol Lett Article • There is amino acid sequence homology between the ADP-ribose binding sites of human PARP14 and SARS-CoV-2 ADRP. • This homology is even more pronounced in bat species. • The model proposed highlights the potential of the PARP axis to yield druggable targets for the treatment of COVID-19. European Federation of Immunological Societies. Published by Elsevier B.V. 2020-08 2020-06-11 /pmc/articles/PMC7289111/ /pubmed/32534867 http://dx.doi.org/10.1016/j.imlet.2020.05.008 Text en © 2020 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Webb, Thomas E.
Saad, Ramy
Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase
title Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase
title_full Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase
title_fullStr Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase
title_full_unstemmed Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase
title_short Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase
title_sort sequence homology between human parp14 and the sars-cov-2 adp ribose 1’-phosphatase
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289111/
https://www.ncbi.nlm.nih.gov/pubmed/32534867
http://dx.doi.org/10.1016/j.imlet.2020.05.008
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