Platelet activation via dynamic conformational changes of von Willebrand factor under shear

Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed. Cumulative effect of dynamic shear on platelet activation via conformational ch...

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Detalles Bibliográficos
Autores principales: Pushin, Denis M., Salikhova, Tatiana Y., Zlobina, Ksenia E., Guria, Georgy Th.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289367/
https://www.ncbi.nlm.nih.gov/pubmed/32525962
http://dx.doi.org/10.1371/journal.pone.0234501
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author Pushin, Denis M.
Salikhova, Tatiana Y.
Zlobina, Ksenia E.
Guria, Georgy Th.
author_facet Pushin, Denis M.
Salikhova, Tatiana Y.
Zlobina, Ksenia E.
Guria, Georgy Th.
author_sort Pushin, Denis M.
collection PubMed
description Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed. Cumulative effect of dynamic shear on platelet activation via conformational changes of VWF is analysed. The critical condition of shear-induced platelet activation is formulated. The explicit expression for the threshold value of cumulative shear stress as a function of VWF multimer size is derived. The results open novel prospects for pharmacological regulation of shear-induced platelet activation through control of VWF multimers size distribution.
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spelling pubmed-72893672020-06-15 Platelet activation via dynamic conformational changes of von Willebrand factor under shear Pushin, Denis M. Salikhova, Tatiana Y. Zlobina, Ksenia E. Guria, Georgy Th. PLoS One Research Article Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed. Cumulative effect of dynamic shear on platelet activation via conformational changes of VWF is analysed. The critical condition of shear-induced platelet activation is formulated. The explicit expression for the threshold value of cumulative shear stress as a function of VWF multimer size is derived. The results open novel prospects for pharmacological regulation of shear-induced platelet activation through control of VWF multimers size distribution. Public Library of Science 2020-06-11 /pmc/articles/PMC7289367/ /pubmed/32525962 http://dx.doi.org/10.1371/journal.pone.0234501 Text en © 2020 Pushin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pushin, Denis M.
Salikhova, Tatiana Y.
Zlobina, Ksenia E.
Guria, Georgy Th.
Platelet activation via dynamic conformational changes of von Willebrand factor under shear
title Platelet activation via dynamic conformational changes of von Willebrand factor under shear
title_full Platelet activation via dynamic conformational changes of von Willebrand factor under shear
title_fullStr Platelet activation via dynamic conformational changes of von Willebrand factor under shear
title_full_unstemmed Platelet activation via dynamic conformational changes of von Willebrand factor under shear
title_short Platelet activation via dynamic conformational changes of von Willebrand factor under shear
title_sort platelet activation via dynamic conformational changes of von willebrand factor under shear
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289367/
https://www.ncbi.nlm.nih.gov/pubmed/32525962
http://dx.doi.org/10.1371/journal.pone.0234501
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