Two-step mechanism of J-domain action in driving Hsp70 function

J-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode o...

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Detalles Bibliográficos
Autores principales: Tomiczek, Bartlomiej, Delewski, Wojciech, Nierzwicki, Lukasz, Stolarska, Milena, Grochowina, Igor, Schilke, Brenda, Dutkiewicz, Rafal, Uzarska, Marta A., Ciesielski, Szymon J., Czub, Jacek, Craig, Elizabeth A., Marszalek, Jaroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289447/
https://www.ncbi.nlm.nih.gov/pubmed/32479549
http://dx.doi.org/10.1371/journal.pcbi.1007913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289447/
https://www.ncbi.nlm.nih.gov/pubmed/32479549
http://dx.doi.org/10.1371/journal.pcbi.1007913

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