Assessing parameter uncertainty in small-n pharmacometric analyses: value of the log-likelihood profiling-based sampling importance resampling (LLP-SIR) technique

Assessing parameter uncertainty is a crucial step in pharmacometric workflows. Small datasets with ten or fewer subjects appear regularly in drug development and therapeutic use, but it is unclear which method to assess parameter uncertainty is preferable in such situations. The aim of this study wa...

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Detalles Bibliográficos
Autores principales: Broeker, Astrid, Wicha, Sebastian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289778/
https://www.ncbi.nlm.nih.gov/pubmed/32248328
http://dx.doi.org/10.1007/s10928-020-09682-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289778/
https://www.ncbi.nlm.nih.gov/pubmed/32248328
http://dx.doi.org/10.1007/s10928-020-09682-4

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