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Zoledronic acid regulates the synthesis and secretion of IL-1β through Histone methylation in macrophages

Long-term administration of nitrogen-containing bisphosphonates increases the risk of detrimental side effects, such as bisphosphonate-related osteonecrosis of the jaw (BRONJ). BRONJ development is associated with inflammation, but its pathophysiology remains unknown. Here, we examined whether histo...

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Detalles Bibliográficos
Autores principales: Yang, Xiaojie, Xu, Xing, Chen, Jun, Wang, Qing, Wang, Guangfei, Ai, Xuemin, Wang, Xu, Pan, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289826/
https://www.ncbi.nlm.nih.gov/pubmed/32566254
http://dx.doi.org/10.1038/s41420-020-0273-4