Alterations in TGF-β signaling leads to high HMGA2 levels potentially through modulation of PJA1/SMAD3 in HCC cells

Recently, we observed that the TGF-β pathway is altered in 39% of HCCs. The alterations are correlated with a raised HMGA2 level. Therefore, we compared genetic alterations of HMGA2 and 43 TGF-β pathway core genes in HCC patients from TCGA database. Genetic alterations of 15 genes, including INHBE,...

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Detalles Bibliográficos
Autores principales: Ohshiro, Kazufumi, Chen, Jian, Srivastav, Jigisha, Mishra, Lopa, Mishra, Bibhuti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289907/
https://www.ncbi.nlm.nih.gov/pubmed/32577156
http://dx.doi.org/10.18632/genesandcancer.199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289907/
https://www.ncbi.nlm.nih.gov/pubmed/32577156
http://dx.doi.org/10.18632/genesandcancer.199

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