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Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity o...

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Detalles Bibliográficos
Autores principales: Singla, Shruti, Iwamoto-Stohl, Lisa K., Zhu, Meng, Zernicka-Goetz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290028/
https://www.ncbi.nlm.nih.gov/pubmed/32528010
http://dx.doi.org/10.1038/s41467-020-16796-3