Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells

We studied whether cytosine phosphate–guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccin...

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Detalles Bibliográficos
Autores principales: Trus, Ivan, Berube, Nathalie, Jiang, Peng, Rak, Janusz, Gerdts, Volker, Karniychuk, Uladzimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290362/
https://www.ncbi.nlm.nih.gov/pubmed/32466170
http://dx.doi.org/10.3390/v12050579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290362/
https://www.ncbi.nlm.nih.gov/pubmed/32466170
http://dx.doi.org/10.3390/v12050579

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