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Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells

We studied whether cytosine phosphate–guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccin...

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Detalles Bibliográficos
Autores principales:	Trus, Ivan, Berube, Nathalie, Jiang, Peng, Rak, Janusz, Gerdts, Volker, Karniychuk, Uladzimir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290362/ https://www.ncbi.nlm.nih.gov/pubmed/32466170 http://dx.doi.org/10.3390/v12050579

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