Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells

Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disorder notably characterized by precocious and deadly atherosclerosis. Almost 90% of HGPS patients carry a LMNA p.G608G splice variant that leads to the expression of a permanently farnesylated abnormal form of prelamin-A, refer...

Descripción completa

Detalles Bibliográficos
Autores principales: Bidault, Guillaume, Garcia, Marie, Capeau, Jacqueline, Morichon, Romain, Vigouroux, Corinne, Béréziat, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290406/
https://www.ncbi.nlm.nih.gov/pubmed/32408587
http://dx.doi.org/10.3390/cells9051201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290406/
https://www.ncbi.nlm.nih.gov/pubmed/32408587
http://dx.doi.org/10.3390/cells9051201

Ejemplares similares