Cargando…

Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells

Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disorder notably characterized by precocious and deadly atherosclerosis. Almost 90% of HGPS patients carry a LMNA p.G608G splice variant that leads to the expression of a permanently farnesylated abnormal form of prelamin-A, refer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bidault, Guillaume, Garcia, Marie, Capeau, Jacqueline, Morichon, Romain, Vigouroux, Corinne, Béréziat, Véronique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290406/ https://www.ncbi.nlm.nih.gov/pubmed/32408587 http://dx.doi.org/10.3390/cells9051201

Ejemplares similares

Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives
por: Vigouroux, Corinne, et al.
Publicado: (2018)

HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells
por: Auclair, Martine, et al.
Publicado: (2020)

Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction
por: Le Pelletier, Laura, et al.
Publicado: (2021)

Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment
por: Bourgeois, Christine, et al.
Publicado: (2021)

Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction
por: Xiang, Yaoxian, et al.
Publicado: (2022)

Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients: Alteration of the PPARγ-Dependent Pathways
por: Caron, Martine, et al.
Publicado: (2009)

SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction
por: Gorwood, Jennifer, et al.
Publicado: (2020)

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA
por: Messner, Moritz, et al.
Publicado: (2020)

Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse
por: Osmanagic-Myers, Selma, et al.
Publicado: (2018)

Progerin-Induced Impairment in Wound Healing and Proliferation in Vascular Endothelial Cells
por: Jiang, Yizhi, et al.
Publicado: (2022)

Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells
por: Guénantin, Anne-Claire, et al.
Publicado: (2017)

Progerin guilty of size discrimination
por: Leslie, Mitch
Publicado: (2013)

Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities
por: Ghislain, Mathilde, et al.
Publicado: (2015)

Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53–progerin interaction
por: Luo, Xiaoying, et al.
Publicado: (2019)

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells
por: Aveleira, Célia A, et al.
Publicado: (2020)

Promotion of tumor development in prostate cancer by progerin
por: Tang, Yong, et al.
Publicado: (2010)

New look at the role of progerin in skin aging
por: Skoczyńska, Anna, et al.
Publicado: (2015)

Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
por: Kang, So-mi, et al.
Publicado: (2021)

Specific Biological Features of Adipose Tissue, and Their Impact on HIV Persistence
por: Bourgeois, Christine, et al.
Publicado: (2019)

Mapping of lamin A- and progerin-interacting genome regions
por: Kubben, Nard, et al.
Publicado: (2012)

Antisense Oligonucleotide Induction of Progerin in Human Myogenic Cells
por: Luo, Yue-Bei, et al.
Publicado: (2014)

New therapeutic approaches to HGPS based on progerin inhibition
por: Pellegrini, Camilla
Publicado: (2015)

Expression of progerin does not result in an increased mutation rate
por: Deniaud, Emmanuelle, et al.
Publicado: (2017)

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells
por: Hamczyk, Magda R, et al.
Publicado: (2019)

Endothelial Progenitor Cells Dysfunction and Senescence: Contribution to Oxidative Stress
por: Imanishi, Toshio, et al.
Publicado: (2008)

The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation
por: Beaupere, Carine, et al.
Publicado: (2015)

Author Correction: Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
por: Kang, So-mi, et al.
Publicado: (2021)

Sulforaphane enhances progerin clearance in Hutchinson–Gilford progeria fibroblasts
por: Gabriel, Diana, et al.
Publicado: (2015)

Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells
por: Harhouri, Karim, et al.
Publicado: (2016)

Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells
por: Danielsson, Brooke E., et al.
Publicado: (2020)

ESCRT-III controls nuclear envelope deformation induced by progerin
por: Arii, Jun, et al.
Publicado: (2020)

MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation
por: Harhouri, Karim, et al.
Publicado: (2017)

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin
por: Kreienkamp, Ray, et al.
Publicado: (2018)

Progerin expression disrupts critical adult stem cell functions involved in tissue repair
por: Pacheco, Laurin Marie, et al.
Publicado: (2014)

A new connection between VHL and cancer threads through progerin
por: Kennedy, Brian K
Publicado: (2013)

One week of exposure to sunlight induces progerin expression in human skin
por: Lesiak, Aleksandra, et al.
Publicado: (2017)

Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy
por: Messner, Moritz, et al.
Publicado: (2018)

Progerin modulates the IGF-1R/Akt signaling involved in aging
por: Jiang, Bo, et al.
Publicado: (2022)

circANRIL reduces vascular endothelial injury, oxidative stress and inflammation in rats with coronary atherosclerosis
por: Shi, Peixia, et al.
Publicado: (2020)

Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6
por: Liu, Rong, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_kfsfa7f53n1edgpovn2v9i14eb