hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells

Mutations in the HERG gene encoding the potassium ion channel HERG, represent one of the most frequent causes of long QT syndrome type-2 (LQT2). The same genetic mutation frequently presents different clinical phenotypes in the family. Our study aimed to model LQT2 and study functional differences b...

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Detalles Bibliográficos
Autores principales: Shah, Disheet, Prajapati, Chandra, Penttinen, Kirsi, Cherian, Reeja Maria, Koivumäki, Jussi T., Alexanova, Anna, Hyttinen, Jari, Aalto-Setälä, Katriina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290503/
https://www.ncbi.nlm.nih.gov/pubmed/32392813
http://dx.doi.org/10.3390/cells9051153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290503/
https://www.ncbi.nlm.nih.gov/pubmed/32392813
http://dx.doi.org/10.3390/cells9051153

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