The Functional Role of CONNEXIN 26 Mutation in Nonsyndromic Hearing Loss, Demonstrated by Zebrafish Connexin 30.3 Homologue Model

Nonsyndromic hearing loss (NSHL) is of great clinical importance, and mutations in the GJB2 gene and the encoded human CONNEXIN 26 (CX26) protein play important roles in the genetic pathogenesis. The CX26 p.R184Q mutation was shown to be a dominant-negative effect in our previous study. Previously,...

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Detalles Bibliográficos
Autores principales: Su, Hsuan-An, Lai, Ting-Wei, Li, Shuan-Yow, Su, Tzu-Rong, Yang, Jiann-Jou, Su, Ching-Chyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290585/
https://www.ncbi.nlm.nih.gov/pubmed/32455934
http://dx.doi.org/10.3390/cells9051291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290585/
https://www.ncbi.nlm.nih.gov/pubmed/32455934
http://dx.doi.org/10.3390/cells9051291

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