Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E(2) Activation in Human Podocytes

Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman’s space. Elevated Prostaglandin E2 (PGE(2)) synthesis and upregulated cyclooxygenase 2 (Cox2) are associated wit...

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Detalles Bibliográficos
Autores principales: Mangelsen, Eva, Rothe, Michael, Schulz, Angela, Kourpa, Aikaterini, Panáková, Daniela, Kreutz, Reinhold, Bolbrinker, Juliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290667/
https://www.ncbi.nlm.nih.gov/pubmed/32438662
http://dx.doi.org/10.3390/cells9051256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290667/
https://www.ncbi.nlm.nih.gov/pubmed/32438662
http://dx.doi.org/10.3390/cells9051256

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