UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway

Mutations of Ubiquilin 2 (UBQLN2) or TANK-binding kinase 1 (TBK1) are associated with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD). However, the mechanisms whereby UBQLN2 or TBK1 mutations lead to ALS and FTD remain unclear. Here, we explored the effect of UBQLN2 on TBK1 i...

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Detalles Bibliográficos
Autores principales: Chen, Tianhong, Zhang, Wenjuan, Huang, Bo, Chen, Xuan, Huang, Cao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290724/
https://www.ncbi.nlm.nih.gov/pubmed/32413959
http://dx.doi.org/10.3390/cells9051205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290724/
https://www.ncbi.nlm.nih.gov/pubmed/32413959
http://dx.doi.org/10.3390/cells9051205

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