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UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway

Mutations of Ubiquilin 2 (UBQLN2) or TANK-binding kinase 1 (TBK1) are associated with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD). However, the mechanisms whereby UBQLN2 or TBK1 mutations lead to ALS and FTD remain unclear. Here, we explored the effect of UBQLN2 on TBK1 i...

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Detalles Bibliográficos
Autores principales:	Chen, Tianhong, Zhang, Wenjuan, Huang, Bo, Chen, Xuan, Huang, Cao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290724/ https://www.ncbi.nlm.nih.gov/pubmed/32413959 http://dx.doi.org/10.3390/cells9051205

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