Allosteric Antagonism of the A(2A) Adenosine Receptor by a Series of Bitopic Ligands

Allosteric antagonism by bitopic ligands, as reported for many receptors, is a distinct modulatory mechanism. Although several bitopic A(2A) adenosine receptor (A(2A)AR) ligand classes were reported as pharmacological tools, their receptor binding and functional antagonism patterns, i.e., allosteric...

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Detalles Bibliográficos
Autores principales: Gao, Zhan-Guo, Toti, Kiran S., Campbell, Ryan, Suresh, R. Rama, Yang, Huijun, Jacobson, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290864/
https://www.ncbi.nlm.nih.gov/pubmed/32408534
http://dx.doi.org/10.3390/cells9051200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290864/
https://www.ncbi.nlm.nih.gov/pubmed/32408534
http://dx.doi.org/10.3390/cells9051200

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