Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development

The pathogenesis of Crohn’s disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its receptor (SUCNR1) are involved in intestinal inflammation and fibrosis, we investigated their relevance in EMT and Crohn’s disease (CD) fistula...

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Detalles Bibliográficos
Autores principales: Ortiz-Masiá, Dolores, Gisbert-Ferrándiz, Laura, Bauset, Cristina, Coll, Sandra, Mamie, Céline, Scharl, Michael, Esplugues, Juan V., Alós, Rafael, Navarro, Francisco, Cosín-Roger, Jesús, Barrachina, María D., Calatayud, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290938/
https://www.ncbi.nlm.nih.gov/pubmed/32365557
http://dx.doi.org/10.3390/cells9051104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290938/
https://www.ncbi.nlm.nih.gov/pubmed/32365557
http://dx.doi.org/10.3390/cells9051104

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