Molecular Dynamics Simulations of Influenza A Virus NS1 Reveal a Remarkably Stable RNA-Binding Domain Harboring Promising Druggable Pockets

The non-structural protein NS1 of influenza A viruses is considered to be the major antagonist of the interferon system and antiviral defenses of the cell. It could therefore represent a suitable target for novel antiviral strategies. As a first step towards the identification of small compounds tar...

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Detalles Bibliográficos
Autores principales: Abi Hussein, Hiba, Geneix, Colette, Cauvin, Camille, Marc, Daniel, Flatters, Delphine, Camproux, Anne-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290946/
https://www.ncbi.nlm.nih.gov/pubmed/32422922
http://dx.doi.org/10.3390/v12050537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290946/
https://www.ncbi.nlm.nih.gov/pubmed/32422922
http://dx.doi.org/10.3390/v12050537

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