Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules That Enhance Ca(2+) Transport

We engineered a concatenated fluorescent biosensor and dual-wavelength fluorescence lifetime (FLT) detection, to perform high-throughput screening (HTS) in living cells for discovery of potential heart-failure drugs. Heart failure is correlated with insufficient activity of the sarcoplasmic reticulu...

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Detalles Bibliográficos
Autores principales: Schaaf, Tory M., Kleinboehl, Evan, Yuen, Samantha L., Roelike, Lauren N., Svensson, Bengt, Thompson, Andrew R., Cornea, Razvan L., Thomas, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291019/
https://www.ncbi.nlm.nih.gov/pubmed/32397211
http://dx.doi.org/10.3390/cells9051170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291019/
https://www.ncbi.nlm.nih.gov/pubmed/32397211
http://dx.doi.org/10.3390/cells9051170

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