Cargando…

Yeast-Based Genetic Interaction Analysis of Human Kinome

Kinases are critical intracellular signaling proteins. To better understand kinase-mediated signal transduction, a large-scale human–yeast genetic interaction screen was performed. Among 597 human kinase genes tested, 28 displayed strong toxicity in yeast when overexpressed. En masse transformation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jae-Hong, Seo, Yeojin, Jo, Myungjin, Jeon, Hyejin, Lee, Won-Ha, Yachie, Nozomu, Zhong, Quan, Vidal, Marc, Roth, Frederick P., Suk, Kyoungho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291280/ https://www.ncbi.nlm.nih.gov/pubmed/32392905 http://dx.doi.org/10.3390/cells9051156

Ejemplares similares

Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target
por: Jo, Myungjin, et al.
Publicado: (2017)

Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation
por: Kim, Jae-Hong, et al.
Publicado: (2021)

Human-yeast genetic interaction for disease network: systematic discovery of multiple drug targets
por: Suk, Kyoungho
Publicado: (2017)

Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity
por: Jeon, Hyejin, et al.
Publicado: (2012)

The yeast kinome displays scale free topology with functional hub clusters
por: Lee, Robin EC, et al.
Publicado: (2005)

Kinome Profiling
por: Peppelenbosch, Maikel P.
Publicado: (2012)

Integrative Features of the Yeast Phosphoproteome and Protein–Protein Interaction Map
por: Yachie, Nozomu, et al.
Publicado: (2011)

The Cryptosporidium parvum Kinome
por: Artz, Jennifer D, et al.
Publicado: (2011)

Reconstitution of human RNA interference in budding yeast
por: Suk, Kyoungho, et al.
Publicado: (2011)

Kinomics toolbox—A web platform for analysis and viewing of kinomic peptide array data
por: Dussaq, Alex M., et al.
Publicado: (2018)

A subcellular map of the human kinome
por: Zhang, Haitao, et al.
Publicado: (2021)

Double Selection Enhances the Efficiency of Target-AID and Cas9-Based Genome Editing in Yeast
por: Després, Philippe C, et al.
Publicado: (2018)

Kinome Render: a stand-alone and web-accessible tool to annotate the human protein kinome tree
por: Chartier, Matthieu, et al.
Publicado: (2013)

Structural and Functional Diversity of the Microbial Kinome
por: Kannan, Natarajan, et al.
Publicado: (2007)

Functional Analysis of the Aspergillus nidulans Kinome
por: De Souza, Colin P., et al.
Publicado: (2013)

Large-scale docking approaches to the kinome
por: Schmidt, Denis, et al.
Publicado: (2014)

Protein aggregation profile of the human kinome
por: Graña-Montes, Ricardo, et al.
Publicado: (2012)

Novel cancer drivers: mining the kinome
por: Biankin, Andrew V, et al.
Publicado: (2013)

Unmasking Determinants of Specificity in the Human Kinome
por: Creixell, Pau, et al.
Publicado: (2015)

Reverse Signaling of Tumor Necrosis Factor Superfamily Proteins in Macrophages and Microglia: Superfamily Portrait in the Neuroimmune Interface
por: Lee, Won-Ha, et al.
Publicado: (2019)

Cathelicidin-Related Antimicrobial Peptide Negatively Regulates Bacterial Endotoxin-Induced Glial Activation
por: Bhusal, Anup, et al.
Publicado: (2022)

Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain
por: Jha, Mithilesh Kumar, et al.
Publicado: (2013)

First Insight into the Kinome of Human Regulatory T Cells
por: König, Sebastian, et al.
Publicado: (2012)

Peptide Arrays for Kinome Analysis of Livestock Species
por: Daigle, Joanna, et al.
Publicado: (2014)

Mechanistic Parameterization of the Kinomic Signal in Peptide Arrays
por: Dussaq, Alex, et al.
Publicado: (2016)

A Synthetic Kinome Microarray Data Generator
por: Maleki, Farhad, et al.
Publicado: (2015)

The Kinome of Edible and Medicinal Fungus Wolfiporia cocos
por: Wei, Wei, et al.
Publicado: (2016)

Large-scale Discovery of Substrates of the Human Kinome
por: Sugiyama, Naoyuki, et al.
Publicado: (2019)

Recent advances in methods to assess the activity of the kinome
por: Radu, Maria, et al.
Publicado: (2017)

Evolution of Functional Diversity in the Holozoan Tyrosine Kinome
por: Yeung, Wayland, et al.
Publicado: (2021)

A framework to efficiently describe and share reproducible DNA materials and construction protocols
por: Mori, Hideto, et al.
Publicado: (2022)

Functional Characterization of Rhoptry Kinome in the Virulent Toxoplasma gondii RH Strain
por: Wang, Jin-Lei, et al.
Publicado: (2017)

Crosstalk between signals initiated from TLR4 and cell surface BAFF results in synergistic induction of proinflammatory mediators in THP-1 cells
por: Lim, Su-Geun, et al.
Publicado: (2017)

Chemogenetic stimulation of the G(i) pathway in astrocytes suppresses neuroinflammation
por: Kim, Jae‐Hong, et al.
Publicado: (2021)

Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration
por: Afridi, Ruqayya, et al.
Publicado: (2020)

Lipocalin-2 in Diabetic Complications of the Nervous System: Physiology, Pathology, and Beyond
por: Bhusal, Anup, et al.
Publicado: (2021)

AiKPro: deep learning model for kinome-wide bioactivity profiling using structure-based sequence alignments and molecular 3D conformer ensemble descriptors
por: Park, Hyejin, et al.
Publicado: (2023)

Kinome expression profiling and prognosis of basal breast cancers
por: Sabatier, Renaud, et al.
Publicado: (2011)

The Arabidopsis Kinome: phylogeny and evolutionary insights into functional diversification
por: Zulawski, Monika, et al.
Publicado: (2014)

Soybean kinome: functional classification and gene expression patterns
por: Liu, Jinyi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3ba4u1dr4s2bq99e5hb4t1h7uu