Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking

Biochemical and genetic studies have indicated that O-linked glycosylation such as O-glucose (Glc), fucose (Fuc), and N-acetylglucosamine (GlcNAc) is critical for Notch signaling; however, it is not fully understood how O-glycans regulate the Notch receptor function. Notch receptors are type-I trans...

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Detalles Bibliográficos
Autores principales: Urata, Yusuke, Saiki, Wataru, Tsukamoto, Yohei, Sago, Hiroaki, Hibi, Hideharu, Okajima, Tetsuya, Takeuchi, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291291/
https://www.ncbi.nlm.nih.gov/pubmed/32423029
http://dx.doi.org/10.3390/cells9051220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291291/
https://www.ncbi.nlm.nih.gov/pubmed/32423029
http://dx.doi.org/10.3390/cells9051220

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