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Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain

BACKGROUND: Recently, mineralocorticoid receptors (MR) were identified in peripheral nociceptive neurons, and their acute antagonism was responsible for immediate and short-lasting (non-genomic) antinociceptive effects. The same neurons were shown to produce the endogenous ligand aldosterone by the...

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Detalles Bibliográficos
Autores principales: Shaqura, Mohammed, Li, Li, Mohamed, Doaa M., Li, Xiongjuan, Treskatsch, Sascha, Buhrmann, Constanze, Shakibaei, Mehdi, Beyer, Antje, Mousa, Shaaban A., Schäfer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291517/
https://www.ncbi.nlm.nih.gov/pubmed/32532285
http://dx.doi.org/10.1186/s12974-020-01864-8