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Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins

The release of DNA into the cytoplasm upon damage to the nucleus or during viral infection triggers an interferon-mediated defense response, inflammation and cell death. In human cells cytoplasmic DNA is sensed by cyclic GMP-AMP Synthase (cGAS) and Absent In Melanoma 2 (AIM2). Here, we report the id...

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Detalles Bibliográficos
Autores principales: Fischer, Heinz, Tschachler, Erwin, Eckhart, Leopold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291609/
https://www.ncbi.nlm.nih.gov/pubmed/32533513
http://dx.doi.org/10.1007/s10495-020-01614-4