An 8 week open-label interventional multicenter study to explore the lung clearance index as endpoint for clinical trials in cystic fibrosis patients ≥8 years of age, chronically infected with Pseudomonas aeruginosa

BACKGROUND: Forced expiratory volume in 1 second (FEV(1)) is the only parameter currently recognized as a surrogate endpoint in cystic fibrosis (CF) trials. However, FEV(1) is relatively insensitive to changes in the small airways of patients with milder lung disease. This pilot study aimed to explo...

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Detalles Bibliográficos
Autores principales: Sutharsan, Sivagurunathan, Naehrig, Susanne, Mellies, Uwe, Sieder, Christian, Ziegler, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291662/
https://www.ncbi.nlm.nih.gov/pubmed/32532226
http://dx.doi.org/10.1186/s12890-020-01201-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291662/
https://www.ncbi.nlm.nih.gov/pubmed/32532226
http://dx.doi.org/10.1186/s12890-020-01201-y

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