Laparoscopic based renal denervation in a canine neurogenic hypertension model
BACKGROUND: Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. METHODS: Sixteen Beagle dogs were randoml...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291739/ https://www.ncbi.nlm.nih.gov/pubmed/32527220 http://dx.doi.org/10.1186/s12872-020-01546-6 |
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author | Shao, Chunlai Zhou, Yan You, Tao Xue, Boxin Stella, Pieter R. Jiang, Ting Bo Miao, Zhigang Xu, Longjiang Yin Lan, Longsheng Rong, Guang |
author_facet | Shao, Chunlai Zhou, Yan You, Tao Xue, Boxin Stella, Pieter R. Jiang, Ting Bo Miao, Zhigang Xu, Longjiang Yin Lan, Longsheng Rong, Guang |
author_sort | Shao, Chunlai |
collection | PubMed |
description | BACKGROUND: Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. METHODS: Sixteen Beagle dogs were randomly divided into RDN group (n = 12) and sham group (n = 4). Neurogenic hypertension was generated in all dogs via carotid artery route. L-RDN was performed in the RDN group, with sham operation performed as a control. Blood pressure (BP) changes were recorded at 2, 4, 6, and 8 weeks after the procedure. Changes in serum creatinine (sCr), blood urea nitrogen (BUN) and level of norepinephrine (NE) were analyzed. Histological changes of kidney and renal arteries were also evaluated. RESULTS: BP and NE levels were significantly elevated after hypertension induction (p < 0.01). Systolic and diastolic BP of RDN group were decreased by 15.5 mmHg and 7.3 mmHg (p < 0.0001 and p = 0.0021, respectively) at the eighth week after L-RDN. Invasive systolic and diastolic BP of RDN group were significantly decreased by 14.5 mmHg and 15.3 mmHg (p < 0.0001). In contrast, there was no significant decrease in blood pressure in the sham group. In addition, RDN group but not the sham group showed a significant decrease in NE levels (p < 0.001), while no significant changes in sCr and BUN were observed in both groups. Pathological examinations showed no discernible damage, tear, or dissection to the renal arteries in RND group. CONCLUSIONS: L-RDN lowered BP and NE levels in hypertensive dogs without affecting renal artery morphology and kidney function. |
format | Online Article Text |
id | pubmed-7291739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72917392020-06-12 Laparoscopic based renal denervation in a canine neurogenic hypertension model Shao, Chunlai Zhou, Yan You, Tao Xue, Boxin Stella, Pieter R. Jiang, Ting Bo Miao, Zhigang Xu, Longjiang Yin Lan, Longsheng Rong, Guang BMC Cardiovasc Disord Research Article BACKGROUND: Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. METHODS: Sixteen Beagle dogs were randomly divided into RDN group (n = 12) and sham group (n = 4). Neurogenic hypertension was generated in all dogs via carotid artery route. L-RDN was performed in the RDN group, with sham operation performed as a control. Blood pressure (BP) changes were recorded at 2, 4, 6, and 8 weeks after the procedure. Changes in serum creatinine (sCr), blood urea nitrogen (BUN) and level of norepinephrine (NE) were analyzed. Histological changes of kidney and renal arteries were also evaluated. RESULTS: BP and NE levels were significantly elevated after hypertension induction (p < 0.01). Systolic and diastolic BP of RDN group were decreased by 15.5 mmHg and 7.3 mmHg (p < 0.0001 and p = 0.0021, respectively) at the eighth week after L-RDN. Invasive systolic and diastolic BP of RDN group were significantly decreased by 14.5 mmHg and 15.3 mmHg (p < 0.0001). In contrast, there was no significant decrease in blood pressure in the sham group. In addition, RDN group but not the sham group showed a significant decrease in NE levels (p < 0.001), while no significant changes in sCr and BUN were observed in both groups. Pathological examinations showed no discernible damage, tear, or dissection to the renal arteries in RND group. CONCLUSIONS: L-RDN lowered BP and NE levels in hypertensive dogs without affecting renal artery morphology and kidney function. BioMed Central 2020-06-11 /pmc/articles/PMC7291739/ /pubmed/32527220 http://dx.doi.org/10.1186/s12872-020-01546-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Shao, Chunlai Zhou, Yan You, Tao Xue, Boxin Stella, Pieter R. Jiang, Ting Bo Miao, Zhigang Xu, Longjiang Yin Lan, Longsheng Rong, Guang Laparoscopic based renal denervation in a canine neurogenic hypertension model |
title | Laparoscopic based renal denervation in a canine neurogenic hypertension model |
title_full | Laparoscopic based renal denervation in a canine neurogenic hypertension model |
title_fullStr | Laparoscopic based renal denervation in a canine neurogenic hypertension model |
title_full_unstemmed | Laparoscopic based renal denervation in a canine neurogenic hypertension model |
title_short | Laparoscopic based renal denervation in a canine neurogenic hypertension model |
title_sort | laparoscopic based renal denervation in a canine neurogenic hypertension model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291739/ https://www.ncbi.nlm.nih.gov/pubmed/32527220 http://dx.doi.org/10.1186/s12872-020-01546-6 |
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