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Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease

Lysine acetylation is one of the major posttranslational modifications (PTM) in human cells and thus needs to be tightly regulated by the writers of this process, the histone acetyl transferases (HAT), and the erasers, the histone deacetylases (HDAC). Acetylation plays a crucial role in cell signali...

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Detalles Bibliográficos
Autores principales: Kulka, Linda Anna Michelle, Fangmann, Pia-Victoria, Panfilova, Diana, Olzscha, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291789/
https://www.ncbi.nlm.nih.gov/pubmed/32582706
http://dx.doi.org/10.3389/fcell.2020.00425