Cargando…

Functions and Clinical Significance of UPF3a Expression in Human Colorectal Cancer

BACKGROUND: Nonsense-mediated mRNA decay (NMD) can degrade mRNAs with a premature termination codon (PTC), and undegraded mRNAs with PTC mutations can induce a genetic compensation response (GCR) by upregulating its compensatory genes. UPF3a refers to up-frame shift 3A (UPF3a) participating in NMD p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bao, Xinmin, Huang, Yuji, Xu, Weimin, Xiong, Gongyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292372/ https://www.ncbi.nlm.nih.gov/pubmed/32606924 http://dx.doi.org/10.2147/CMAR.S244486

Ejemplares similares

Human UPF3A and UPF3B enable fault‐tolerant activation of nonsense‐mediated mRNA decay
por: Wallmeroth, Damaris, et al.
Publicado: (2022)

Dual function of UPF3B in early and late translation termination
por: Neu‐Yilik, Gabriele, et al.
Publicado: (2017)

Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation
por: Bufton, Joshua C, et al.
Publicado: (2022)

HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA
por: Ajamian, Lara, et al.
Publicado: (2015)

Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1
por: Kalathiya, Umesh, et al.
Publicado: (2019)

Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding
por: Yi, Zhongxia, et al.
Publicado: (2022)

UPF1—From mRNA Degradation to Human Disorders
por: Staszewski, Jacek, et al.
Publicado: (2023)

Amlexanox and UPF1 Modulate Wnt Signaling and Apoptosis in HCT-116 Colorectal Cancer Cells
por: Bordonaro, Michael, et al.
Publicado: (2019)

The feedback control of UPF3 is crucial for RNA surveillance in plants
por: Degtiar, Evgeniya, et al.
Publicado: (2015)

Full UPF3B function is critical for neuronal differentiation of neural stem cells
por: Alrahbeni, Tahani, et al.
Publicado: (2015)

Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner
por: Xie, Aixuan, et al.
Publicado: (2023)

UPF2 Is a Critical Regulator of Liver Development, Function and Regeneration
por: Thoren, Lina A., et al.
Publicado: (2010)

UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer
por: Zhu, Congcong, et al.
Publicado: (2021)

The role of the NMD factor UPF3B in olfactory sensory neurons
por: Tan, Kun, et al.
Publicado: (2020)

A Upf3b-mutant mouse model with behavioral and neurogenesis defects
por: Huang, L, et al.
Publicado: (2018)

Expression and clinical significance of METTL3 in colorectal cancer
por: Li, Hui, et al.
Publicado: (2023)

The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level
por: Rao, Shringar, et al.
Publicado: (2018)

DNA substrate recognition and processing by the full-length human UPF1 helicase
por: Dehghani-Tafti, Saba, et al.
Publicado: (2017)

Interaction Between LncRNA and UPF1 in Tumors
por: He, Junjian, et al.
Publicado: (2021)

UPF1 Participates in the Progression of Endometrial Cancer by Inhibiting the Expression of lncRNA PVT1
por: Xing, Tian-rong, et al.
Publicado: (2020)

The clinical significance of CCBE1 expression in human colorectal cancer
por: Zhao, Yan-Rong, et al.
Publicado: (2018)

Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer
por: Xiong, Hui, et al.
Publicado: (2017)

Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas
por: Gallardo-Gómez, María, et al.
Publicado: (2023)

The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer
por: Wu, Zi-Xin, et al.
Publicado: (2021)

Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1
por: Lasalde, Clarivel, et al.
Publicado: (2014)

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma
por: Polaski, Jacob T, et al.
Publicado: (2021)

Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG
por: Cheng, Yaojia, et al.
Publicado: (2020)

Initial Alignment of Large Azimuth Misalignment Angles in SINS Based on Adaptive UPF
por: Sun, Jin, et al.
Publicado: (2015)

UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma
por: Zhang, Minfen, et al.
Publicado: (2021)

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains
por: Fiorini, Francesca, et al.
Publicado: (2013)

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities
por: Fiorini, Francesca, et al.
Publicado: (2015)

Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer
por: Liu, Chun-Yu, et al.
Publicado: (2021)

Interactions between Upf1 and the Decapping Factors Edc3 and Pat1 in Saccharomyces cerevisiae
por: Swisher, Kylie D., et al.
Publicado: (2011)

Expression and Clinical Significance of ERCC1 and XPF in Human Hepatocellular Carcinoma
por: Liao, Xiaoli, et al.
Publicado: (2020)

UPF1-like helicase grip on nucleic acids dictates processivity
por: Kanaan, Joanne, et al.
Publicado: (2018)

Nuclear UPF1 Is Associated with Chromatin for Transcription-Coupled RNA Surveillance
por: Hong, Dawon, et al.
Publicado: (2019)

UPF1 helicase promotes TSN-mediated miRNA decay
por: Elbarbary, Reyad A., et al.
Publicado: (2017)

UPF1-Mediated RNA Decay—Danse Macabre in a Cloud
por: Lavysh, Daria, et al.
Publicado: (2020)

UPF1: From mRNA Surveillance to Protein Quality Control
por: Hwang, Hyun Jung, et al.
Publicado: (2021)

Progression of the pluripotent epiblast depends upon the NMD factor UPF2
por: Chousal, Jennifer N., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v0qkigmu8u2trc3qqdhjnvo6ko