Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

Interpretations of elevated blood levels of alanine aminotransferase (ALT) for drug-induced liver injury often assume that the biomarker is released passively from dying cells. However, the mechanisms driving that release have not been explored experimentally. The usefulness of ALT and related bioma...

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Detalles Bibliográficos
Autores principales: Smith, Andrew K., Ropella, Glen E. P., McGill, Mitchell R., Krishnan, Preethi, Dutta, Lopamudra, Kennedy, Ryan C., Jaeschke, Hartmut, Hunt, C. Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292418/
https://www.ncbi.nlm.nih.gov/pubmed/32484845
http://dx.doi.org/10.1371/journal.pcbi.1007622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292418/
https://www.ncbi.nlm.nih.gov/pubmed/32484845
http://dx.doi.org/10.1371/journal.pcbi.1007622

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