A highly potent lymphatic system–targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus

Cyclosporine A (CsA) is a powerful immunosuppressant, but it is an ineffective stand-alone treatment for systemic lupus erythematosus (SLE) due to poor target tissue distribution and renal toxicity. We hypothesized that CD71 (transferrin receptor 1)–directed delivery of CsA to the lymphatic system w...

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Detalles Bibliográficos
Autores principales: Ganugula, Raghu, Arora, Meenakshi, Zou, Dianxiong, Agarwal, Sandeep K., Mohan, Chandra, Kumar, M. N. V. Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292630/
https://www.ncbi.nlm.nih.gov/pubmed/32582860
http://dx.doi.org/10.1126/sciadv.abb3900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292630/
https://www.ncbi.nlm.nih.gov/pubmed/32582860
http://dx.doi.org/10.1126/sciadv.abb3900

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