The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint

During mitosis, the Spindle Assembly Checkpoint (SAC) maintains genome stability while also ensuring timely anaphase onset. To maintain genome stability, the SAC must be strong to delay anaphase even if just one chromosome is unattached, but for timely anaphase onset, it must promptly respond to sil...

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Detalles Bibliográficos
Autores principales: Roy, Babhrubahan, Han, Simon JY, Fontan, Adrienne Nicole, Joglekar, Ajit P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292645/
https://www.ncbi.nlm.nih.gov/pubmed/32479259
http://dx.doi.org/10.7554/eLife.55096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292645/
https://www.ncbi.nlm.nih.gov/pubmed/32479259
http://dx.doi.org/10.7554/eLife.55096

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