Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

Recently evolved alleles of Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels within the parasite, ca...

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Detalles Bibliográficos
Autores principales: Giovinazzo, Joseph A, Thomson, Russell P, Khalizova, Nailya, Zager, Patrick J, Malani, Nirav, Rodriguez-Boulan, Enrique, Raper, Jayne, Schreiner, Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292663/
https://www.ncbi.nlm.nih.gov/pubmed/32427098
http://dx.doi.org/10.7554/eLife.51185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292663/
https://www.ncbi.nlm.nih.gov/pubmed/32427098
http://dx.doi.org/10.7554/eLife.51185

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