Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis

BACKGROUND: Application of idarucizumab and hemodialysis are options to reverse the action of the oral anticoagulant dabigatran in emergency situations. OBJECTIVES: The objectives of this study were to build and evaluate a mechanistic, whole-body physiologically based pharmacokinetic/pharmacodynamic...

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Detalles Bibliográficos
Autores principales: Fuhr, Laura Maria, Hanke, Nina, Meibohm, Bernd, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292816/
https://www.ncbi.nlm.nih.gov/pubmed/32020532
http://dx.doi.org/10.1007/s40262-019-00857-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292816/
https://www.ncbi.nlm.nih.gov/pubmed/32020532
http://dx.doi.org/10.1007/s40262-019-00857-y

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